Clinical Evidence

ClinicalEVIDENCE Newsletter

Newsletter #4 – December 2024

December Issue

Welcome to the ClinicalEVIDENCE newsletter, your go-to source for the latest clinical data on heart diseases, diagnostics, and monitoring.

Our aim is to provide you with cutting-edge information that will keep you up to date on the most recent advancements in the field of heart failure management and sudden cardiac death prevention.

NEW: Prof Matteo Bertini’s comment on this edition of the ClinicalEVIDENCE newsletter:

Matteo Bertini, M.D, PhD, FAIAC
Professor of Cardiology, Head of EP lab, Cardiological Center, Sant’ Anna University Hospital

The impact of battery longevity is impressive! 

This issue highlights terrific cost savings per person based on different battery longevity. Beyond cost savings, it’s crucial to stress the reduced risk of complications from replacements.

Considering these data & evidence on infection risks related to replacements, during first device implantation, especially CRT-D, battery longevity should be a key factor. This is a rare case where evidence-based clinical practice aligns perfectly with healthcare cost savings.

Delve into this newsletter to learn more.

Summary

This edition of Clinical Evidence offers an overview of extended CRT-D battery performance and benefit, provides an in-depth summary of the evidence supporting S-ICD journey and delve into the first data about the EMPOWER leadless pacemaker. 

An economic analysis1 confirms the significant cost-saving associated with the use of extended battery longevity (2.1Ah) in CRT-D devices. 

Key Takeaways

  1. CRT-D extended battery longevity and economic impact: Extended longevity CRT-D devices leads to minimizing replacements and enhances patient care cost-effectiveness. This data suggest long-term economic factors should be accounted for in device selection.¹ 
  2. A literature review supporting S-ICD as a valid alternative to TV-ICD: The S-ICD has emerged as a valid and safe alternative to the TV-ICD, reinforced by a decade of consolidated clinical evidence and continuous technological advancements.²
  3. New data on pacing performance of the EMPOWER : New data on pacing performance of the EMPOWER : New data from MODULAR ATP Trial demonstrated safety and efficacy on the pacing performance of the first Boston scientific leadless pacemaker.³

Gain deeper insights by downloading the full newsletter

Clinical EVIDENCE

Newsletter 2024 #4

Now Available in PDF Format


References:

  1. Williams JL, Ryoko S, Jacobsen CM. Cost Savings Associated with Extended Battery Longevity in Cardiac Resynchronization Therapy Defibrillators (CRT-D). Heart Rhythm O2, article in press;. https://doi.org/10.1016/j.hroo.2024.09.008. 
  2. Magnani S, Ali H, Cappato R. Ten years of subcutaneous defibrillator therapy: Consolidated clinical evidence and future perspectives. J Cardiovasc Electrophysiol. 2024 Mar;35(3):601-607. https://doi.org/10.1111/jce.16171. 
  3. Mont L, MS Lloyd, C Blomstrom-Lundqvist et al. Pacing Performance of the First Leadless Pacemaker Communicating with an S-ICD from the full cohort of the MODULAR ATP study. Presented at ESC Congress 2024 and available on ESC 365 platform.