Time Course of HF Decompensation¹
Emulating Clinical Assessment via Physiologic Sensor Monitoring
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Electrophysiology Insights
HeartLogic uses automated intelligence to streamline your ability to see each patient’s physiologic response to arrhythmic and pacing changes.
Relationship Between Atrial Fibrillation and HeartLogic Index²
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HeartLogic May Detect Sub-Optimal BiV Pacing and Poor Physiologic Response³
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HeartLogic May Identify Patients Vulnerable to RV Pacing⁴
![](/en-EU/medical-specialties/electrophysiology/heartlogic-heart-failure-diagnostic/clinical-data/_jcr_content/root/container/container_947831390/container_1510545751/container/image.coreimg.jpeg/1693216391483/clinical-data-rv-chart.jpeg)
MANAGE-HF Study⁵
Phase I of the MANAGE-HF study enrolled 200 patients implanted with a CRT-D or ICD enabled with HeartLogic. The study found that HeartLogic was safely integrated into clinical practice and associated with lower natriuretic peptide levels and hospitalization rates.⁶
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MORE RAPID RECOVERY
Of HeartLogic Index
![](/en-EU/medical-specialties/electrophysiology/heartlogic-heart-failure-diagnostic/clinical-data/_jcr_content/root/container/container_947831390/container_1510545751/container_1683880222_28668145/image_547902262_copy.coreimg.jpeg/1693216796537/lower-icon-768.jpeg)
LOWER
NTproBNP Levels
![](/en-EU/medical-specialties/electrophysiology/heartlogic-heart-failure-diagnostic/clinical-data/_jcr_content/root/container/container_947831390/container_1510545751/container_1683880222/image_547902262.coreimg.jpeg/1693216928652/67-reduc-768.jpeg)
67% REDUCTION
In HF Hospitalizations Associated with HeartLogic*
*Compared with pre-study hospitalization rate (12 months).
MultiSENSE Study Results⁷
The MultiSENSE study assessed more than 900 patients and validated that the HeartLogic algorithm provides a sensitive and timely predictor of impending heart failure decompensation.
![](/en-EU/medical-specialties/electrophysiology/heartlogic-heart-failure-diagnostic/clinical-data/_jcr_content/root/container/container_947831390/container_1510545751/container_1683880222_841469091/image_547902262_copy.coreimg.jpeg/1693217558735/70-sensitivity.jpeg)
70% SENSITIVITY
in Detecting Heart Failure Events
![](/en-EU/medical-specialties/electrophysiology/heartlogic-heart-failure-diagnostic/clinical-data/_jcr_content/root/container/container_947831390/container_1510545751/container_1683880222_1760405585/image_547902262_copy.coreimg.jpeg/1693217628724/34-days.jpeg)
A MEDIAN OF 34 DAYS
Advance Notice of Worsening Heart Failure
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<2 TOTAL ALERTS
Per Patient Per Year
Real-World Evidence
In real-world analyses of nearly 500 patients across four studies, HeartLogic was shown to provide consistent heart failure detection performance with low unexplained alert rates.
Real-World Results Compared to Validation Data Set
SENSITIVITY | UNEXPLAINED ALERT RATE | |
MultiSENSE⁷ (Validation Data Set) | 70% | 1.47 |
Capucci et al.² (ESC HF 2019) | 100%* | 0.41 |
Santini et al.⁸ (Clin Card 2020) | 69%* | 0.37 |
RE-HEART Phase I⁹ (ESC HF 2020) | N/A | 0.25 |
RE-HEART Phase II¹⁰ (ESC HF 2020) | N/A | 0.13 |
Highlights from Real-World Studies
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80% OF ALERTS
Provided New Information to Clinicians⁸
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ALERTS PRECEDED HF SYMPTOMS
by a Median of 12 Days²
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ALERTS PRECEDED HF EVENTS
by a Median of 38 Days²
HeartLogic reduces hospitalisations for decompensated heart failure and significantly reduces the costs per patient for the healthcare system, as described in the Heggermont et al publication.¹¹
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Results from APAF-Mortality Clinical Trial CRT Ablate and Pace – Proven Best Option
Professor Michele Brignole and Isabelle van Gelder reviewed clinical data coming from the APAF-CRT Mortality trial which has made very clear that Ablation + CRT was superior to pharmacological therapy in reducing mortality in patients with permanent AF.
These new and powerful results strengthens and supports the CRT therapy also for these indicated patients.