Clinical Evidence

ClinicalEVIDENCE Newsletter

Newsletter #5 – March 2025

March Issue

Welcome to the ClinicalEVIDENCE newsletter, your go-to source for the latest clinical data on heart diseases, diagnostics, and monitoring.

Our aim is to provide you with cutting-edge information that will keep you up to date on the most recent advancements in the field of heart failure management and sudden cardiac death prevention.

Summary

This edition of Clinical Evidence reviews adherence to remote monitoring (RM) recommendations in CIEDs follow-up and innovations to enhance this technology, focusing on Heart Connect's preliminary experience. It also explores findings from a sub-analysis of the PRAETORIAN study.

An analysis¹ of LATITUDE™ RM system data shows growing RM use but highlights critical aspects for effective clinical practice with high volumes of visits. Heart Connect, a real-time remote technical support service, has proven² feasible, effective, and well-accepted for providing prompt support during in-person CIED follow-up. The PRAETORIAN sub-analysis³ demonstrated comparable rates of inappropriate therapies between S-ICD and TV-ICD in the conventional ICD population, though these results should be reconsidered with recent S-ICD advancements.

Key Takeaways

  1. Adherence to remote monitoring guidelines for CIEDs in clinical practice: RM use is growing in clinical practice, but critical issues remain for its effectiveness, efficiency, and sustainability in real-life. To address these challenges and improve its use, innovative solutions have been introduced to support physicians¹.
  2. Real-time Remote Technical Support for CIED Follow-up: Remote support using HeartConnect™ during CIED follow-up proved feasible, effective, and well-accepted by operators, offering a viable alternative to on-site IEAPs support for follow-up visits².
  3. Insights from the PRAETORIAN Trial: This multicenter randomised study found no significant difference in inappropriate therapy rates and IAS rates between the S-ICD and TV-ICD in a conventional ICD population³.

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References:

  1. Bertini M, D’Onofrio A, Piacenti M et al. Current clinical practice versus remote monitoring recommendations for Cardiovascular Implantable Electronic Devices: A real-world analysis from a remote monitoring database. Heart Rhythm O2. doi:10.1016/j.hroo.2024.11.024.
  2. Bianchi V, Negroni MS, Pecora D et al. Real-time Technical Support Using a Remote Technology During Cardiac Implantable Electronic Device Follow-up: A Preliminary Multicenter Experience in Clinical Practice. J Innov Card Rhythm Manag. 2024 Nov 15;15(11):6070-6078. doi: 10.19102/icrm.2024.15114. 
  3. Olde Nordkamp LRA, Pepplinkhuizen S, Ghani A, et al. Inappropriate Therapy and Shock Rates Between the Subcutaneous and Transvenous Implantable Cardiac Defibrillator: A Secondary Analysis of the PRAETORIAN Trial. Circ Arrhythm Electrophysiol. 2024 Dec;17(12):e012836. doi: 10.1161/CIRCEP.124.012836.