3 HCC patients

For your patients with unresectable hepatocellular carcinoma Personalised and versatile TheraSphereTM Y90 Therapy

EMBRACE THE POWER OF HOPE1,2

Deliver better long-term outcomes with effective downstaging or bridging treatment1

Patient on wheelschair

TheraSphere Y90 Therapy not only provides you and your patients with time to bridge to future treatments, but can allow downstaging of the tumour to access curative surgery options.

Extend mOS to 12.5 years post liver transplant*1

Treatment-naïve patients with unresectable HCC

➣ 12.5 years mOS in patients with unresectable HCC who underwent liver transplants following bridging or downstaging with TheraSphere Y90 Therapy1

15-year data, Gabr et al. 20211

Overall survival of transplant patients

15-year data, Gabr et al. 2021 - Overall survival
  • 12.5 years median OS following liver transplant
    (95% CI: 120–150)

Access curative options

Patients with stage T3 unresectable HCC

➣ ~2x patients with unresectable HCC downstaged from stage T3 to T2 following TheraSphere Y90 Therapy vs cTACE, achieving  transplant eligibility3

Lewandowski et al. 20093

Proportion of patients downstaged

Lewandowski et al. 2009- Downstaging

This trend favouring TheraSphere Y90 Therapy for downstaging was maintained for all lesion sizes.


Prolong progression-free survival

Patients with early and intermediate HCC unfavourable for ablation and unresectable

➣ >26 months of TTP in patients following TheraSphere Y90 Therapy vs cTACE4

Salem et al. 20164

Median time to progression comparison

Salem et al. 2016 - Time to progression
  • >26 months median TTP with TheraSphere Y90 Therapy
    6.8 months median TTP with cTACE
    HR: 0.122
    (95% CI: 0.027–0.557; P=0.007)

Bridge safely and promote future liver remnant

Patients who underwent surgical resection

➣ All patients with unilobar HCC achieved disease control following neoadjuvant TheraSphere Y90 Therapy4
➣ 77% of tumours showed more than 50% pathologic necrosis at resection4

Longitudinally clinical and radiological outcomes study, Gabr et al. 20185

Longitudinally clinical and radiological outcomes study Gabr et al. 2018

*From liver transplant, median OS was 12.5 years (95% CI:120-150).

References

1.Gabr A, al. Liver Transplantation Following Yttrium‐90 Radioembolization: 15‐year Experience in 207‐Patient Cohort. Hepatology 2021;73(3):998-1010.

2.DOSISPHERE-01: Garin E, et al. Personalised versus standard dosimetry approach of selective internal radiation therapy in patients with locally advanced hepatocellular carcinoma (DOSISPHERE-01): a randomised, multicentre, open-label phase 2 trial. Lancet Gastroenterol Hepatol. 2021 Jan;6(1):17-29.

3.Lewandowski RJ, et al. A comparative analysis of transarterial downstaging for hepatocellular carcinoma: chemoembolization versus radioembolization. Am J Transplant. 2009;9(8):1920-8.

4.Salem R, et al. Y90 Radioembolization Significantly Prolongs Time to Progression Compared With Chemoembolization in Patients With Hepatocellular Carcinoma. Gastroenterology. 2016;151(6):1155-1163.e2.

5.Gabr A, et al. Outcomes of Surgical Resection after Radioembolization for Hepatocellular Carcinoma. J Vasc Interv Radiol. 2018;29(11):1502-1510.e1.

Abbreviations

BCLC, Barcelona Clinic Liver Cancer; CI, confidence interval; HCC, hepatocellular carcinoma; HR, hazard ratio; OS, overall survival; RFS, recurrence-free survival; TACE, transarterial chemoembolisation; TTP, time to progression; UNOS, United Network for Organ Sharing; Y90, yttrium-90.

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TheraSphere is a registered trademark of Theragenics Corporation, used under license by Boston Scientific Medical Device Limited, a wholly owned indirect subsidiary of Boston Scientific Corporation.

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