RightRate™
Minute Ventilation
Chronotropic Incompetence (CI)
CI is defined as the inability to achieve the optimal heart rate during activity. If cardiac device patients can’t get their heart rate to increase, it makes it difficult to exercise and perform everyday activities like walking to the mailbox or holding a grandchild. Patients with CI have a higher risk of mortality1,2 and may not be able to achieve a high enough heart rate for normal activities.
Typical Necessary Heart Rate for Activity
CI Prevalence by Condition
Prevalence
While common across the entire heart failure patient population, CI is especially prevalent in patients requiring cardiac resynchronization therapy (CRT).
CI Prevelence by Study Population
| Population | Number | CI% | |
|---|---|---|---|
| HF | Brubaker et al.3 | State of the Art | 25-75%* |
| Witte et al.4 | 237 | 43% | |
| Al-Najjar et al.5 | 411 | 46% | |
| Jorde et al.6 | 278 | 46% | |
| CRT | Samara et al.7 | 238 | 77% |
| Ujeyl et al.8 | 122 | 56-89% |
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RESONATE™ HF CRT-D: Indications, Safety and Warnings
ACCOLADE™ MRI EL: Indications, Safety and Warnings
VISIONIST™ X4 CRT-P: Indications, Safety and Warnings