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With Level 1, Long-Term, and Quality of Life data, EKOS is the most studied device in the space.
Study  nameStudy  description (Level)Status
 Venous thromboembolism: Deep venous thrombosis* 
CAVAA randomised controlled multicenter trial comparing ultrasound-accelerated catheter-directed thrombolysis, combined with standard anticoagulant therapy, with standard anticoagulant therapy alone, for acute primary iliofemoral deep vein thrombosis (Level 1)Enrolling
ACCESS PTSAccelerated thrombolysis for post-thrombotic syndrome using the EKOS system (Level 2) Download the data summary
Completed
   
 Venous thromboembolism: Pulmonary embolism 
ULTIMAUltrasound accelerated thrombolysIs of pulmonary embolism (Level 1)Completed
SEATTLE IIA prospective, single-arm, multi-center trial of EKOS for acute pulmonary embolism (Level 2)Completed
OPTALYSE PEStudy of the optimum duration of acoustic pulse thrombolysis procedure in the treatment of acute submassive pulmonary embolism (Level 2)Completed
KNOCOUT PEInternational EKOS registry of the treatment and clinical outcomes of patients with pulmonary embolismCompleted
   
 Arterial occlusion* 
DUETDutch randomized trial comparing standard catheter-directed thrombolysis versus ultrasound-accelerated thrombolysis for thrombo-emoblic infra-inguinalCompleted
DUET IIDutch randomized trial comparing standard catheter-directed thrombolysis versus ultrasound-accelerated thrombolysis for thrombo-emoblic infra-inguinalStart-up
*Safety and effectiveness have not been established in this patient population
 
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