OPTALYSE long-term data
Sustained RV remodeling & improved patient outcomes
In the OPTALYSE study which evaluated the optimal dose/duration of EKOS treatment, patients were followed for one year. In addition to showing quick improvement in RV function, the long-term data showed sustained RV remodeling out to one-year. OPTALYSE was also the first study of an interventional pulmonary embolism (PE) treatment to show improvement in patient quality of life outcomes.1
RV function
RV/LV ratio continued to reduce after 48h
p value <030001@365d
![RV function graph Graph of RV/LV reduction after 48 hours](/en-US/medical-specialties/vascular-surgery/ekos-endovascular-system/clinical-evidence/optalyse-study/_jcr_content/root/container/container_947831390/container_1510545751/image_copy_917444529.coreimg.jpeg/1671137765251/ekos-rv-func-graph.jpeg)
Endurance
Mean 6-minute walk test distance
![Endurance Graph Graph of 6-minute walk test to measure endurance over 1 year](/en-US/medical-specialties/vascular-surgery/ekos-endovascular-system/clinical-evidence/optalyse-study/_jcr_content/root/container/container_947831390/container_1510545751/image_copy_917444529_1636937642.coreimg.jpeg/1671137702261/ekos-endurance-graph.jpeg)
Physical functioning
Mean PROMUS-PF-6b scores
![EKOS phys function graph Graph of PROMUS-PF-6b scores for physical functioning over 1 year](/en-US/medical-specialties/vascular-surgery/ekos-endovascular-system/clinical-evidence/optalyse-study/_jcr_content/root/container/container_947831390/container_1510545751/image_copy_917444529_605956618.coreimg.jpeg/1671137682813/ekos-phys-func-graph.jpeg)
Quality of life
Mean PEmb-QOL scores
![QOL Graph Graph of Pemb-QOL scores for quality of life over 1 year](/en-US/medical-specialties/vascular-surgery/ekos-endovascular-system/clinical-evidence/optalyse-study/_jcr_content/root/container/container_947831390/container_1510545751/image_copy_917444529_886384322.coreimg.jpeg/1671137618203/ekos-qol-graph.jpeg)
1. Tapson V et al. A randomized trial of the optimum duration of acoustic pulse thrombolysis procedure in acute intermediate-risk pulmonary embolism. JACC: Cardiovascular Interventions 2018; 11(14):1401-1410.