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Medical Specialties > Interventional Cardiology > Coronary Interventions > Clinical Data > Coronary Physiology > Diastolic Hyperemia-Free Ratio™ (DFR™)

Study Methodology & Analysis

Coronary Physiology Overview
FFR
DFR
Pd/Pa

Pooled Analysis from VERIFY 2 and CONTRAST Showed: DFR ™ and iFR™ are Numerically Identical

Methodology of DFR Study1

  • DFR values were compared to iFR values using the 893 waveform tracings from the 833 patients pooled from the VERIFY 2 and CONTRAST studies
  • The DFR window uses two criteria: Pa < mean Pa and down-sloping Pa
  • No ECG signal were required
  • No need to identify dicrotic notch

 

Intermediate Lesion1

DFR: 0.90 | iFR: 0.90
Intermediate Lesion

Severe Lesion1

DFR: 0.71 | iFR: 0.71
Severe Lesion
 
 

DFR is as Accurate to iFR as Two iFR Measurements are to Each Other1

DFR values were compared to iFR values using the 893 waveform tracings from the 833 patients pooled from the VERIFY 2 and CONTRAST studies.1

VERIFY 2 + CONTRAST Pooled Analysis: DFR Showed Equivalency to iFR

VERIFY 2 + CONTRAST Pooled Analysis: DFR Showed Equivalency to iFR

VERIFY 2 Analysis: DFR is within the Intra-iFR Variation of ~0.01

Two iFR Measurements Taken Directly After Each Other
 
Diastolic Pressure Ratio

Diastolic pressure ratio: new approach and validation vs. the instantaneous wave-free ratio2

Read the latest European Heart Journal publication which demonstrates numerical equivalence between DFR and iFR.

Read More
 

dPR = iFR™ 6 Definitions of Proof3

Selecting the wave-free period (wfp) is not necessary to obtain results numerically identical to iFR3

dPR = iFR - 6 Definitions of Proof
 
 

Clinical Outcomes

IRIS-FFR Registry: DFR and iFR Have Equivalent Prognostic Performance in Over 900 Patients4

A total of 1,102 deferred lesions in 926 patients from the IRIS-FFR Registry were retrospectively evaluated by five non‑hyperemic pressure ratios (NHPR), including DFR, for prognostic performance.

  • Greater divergence of the curves demonstrates better prognostic ability
  • There was no statistically significant difference in prognostic performance among any of the NHPRs
DFR
iFR
 
 

Hear From The Experts

Physiology experts discuss new options in Non-Hyperemic Pressure Ratios (NHPR)

Polaris

Which Physiological Index Do You Use?

Watch Morton Kern of UC Irvine, Javier Escaned of Clinico Hospital San Carlos, and Jonathan Hill of King’s College discuss the need for new options in coronary physiology and why pressure guidewire performance matters.

Class Effect Among Non-Hyperemic Pressure Ratios (NHPR)

TCT: Class Effect Among Non-Hyperemic Pressure Ratios (NHPR)

Do all roads lead to Rome when it comes to non-hyperemic pressure ratios (NHPR)? Drs. Morton Kern from UC Irvine, Nils Johnson from UT Houston, and Ziad Ali from Columbia University, discuss data presented at TCT 2018 on new options in coronary physiology, such as DFR, and which tool to use when and why.

Class Effect Among Resting Indices

EuroPCR: Class Effect Among Non-Hyperemic Pressure Ratios (NHPR)

What physiologic assessment do you use? What choices do you have? Cutting-edge measurements are the topic as Drs. Ziad Ali, Luis Raposo, and Keith Oldroyd look at generic forms of resting indices with a 99% correlation to iFR, such as the Diastolic hyperemia-Free Ratio (DFR). Discover new options in coronary physiology presented during EuroPCR 2018. Is there a class effect among all resting indices? Can having more non-hyperemic pressure ratios increase coronary physiology adoption?

DFR Methodology and Analysis

DFR Methodology and Analysis

Dr. Nils Johnson from University of Texas at Houston, discusses DFR methodology and analysis at TCT 2018.

When to Use What in Coronary Physiology and Why

When to Use What in Coronary Physiology and Why

Dr. Ziad Ali from Columbia University Medical Center, discusses when to use what in coronary physiology and why at TCT 2018.

 
 
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