AGENT™

Paclitaxel Coated-PTCA Balloon Catheter
The AGENT Paclitaxel Coated-PTCA Balloon catheter  is the newest advance in drug-coated balloon technology.
Mechanism of action phases

The AGENT™ Paclitaxel Drug Coated Balloon catheter, with its innovative TransPax™ coating technology1, provides a targeted, therapeutic dose of proven, anti-proliferative Paclitaxel to the lesion2. It was designed to minimise downstream particulates while maintaining the outstanding deliverability you’ve come to expect with Boston Scientific products3.

Key Resources

AGENT Drug Coated Balloon Brochure (EN)

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Product Details

The AGENT™ Paclitaxel-Coated balloon catheter, built on the Emerge™ PTCA Balloon Catheter for exceptional deliverability, is indicated for Percutaneous Transluminal Coronary Angioplasty (PTCA) in the coronary arteries to treat in-stent restenosis (ISR) and de novo / small vessel disease.
Optimal dose of 2µg/mm2 compared to 3µg/mm2 of market leading DCBs efficiently achieves sustained benefits of Paclitaxel2 over time.

Optimized Drug Transfer

  • TransPaxTM coating ensures targeted delivery of Paclitaxel†
  • Optimal dose of 2 μg/mm2 compared to 3 μg/mm2 of market leading DCBs‡

Outstanding Deliverability5

  • AgentTM DCB offers exceptional deliverability leveraging the EMERGETM PTCA Catheter:
  • Designed to navigate and cross challenging lesions
    • Ultra-low tip profile
    • Bi-segment inner shaft: flexible distal segment and pushable  proximal segment.

Enhanced Coating Integrity

  • Balanced hydrophobic and hydrophilic properties of Trans PaxTM coating ensures balloon reaches the lesion with the optimal amount of drug for your patient.
  • Fewer particulates are lost distally during the procedure§.
Clinical data access

What is TransPax™

The TransPax coating is a proprietary formulation of Paclitaxel and a citrate ester excipient (acetyl tributyl citrate – ATBC). It leverages Boston Scientific’s history and expertise with paclitaxel and drug coating.

Boston Scientific’s TransPax™ is the coating on both IC and PI Drug-coated balloons (DCB). Ranger™ Paclitaxel-Coated PTA Balloon Catheter is Boston Scientific's DCB for Peripheral Interventions.

 

The TransPax drug coating is a proprietary formulation of Paclitaxel and a citrate ester excipient (ATBC)

What is the Delivery System

AGENT™ Drug-Coated Balloon is built on the Emerge™ balloon catheter technology which combines the best of Boston Scientific balloon technologies to offer exceptional deliverability5 with an ultra-low tip profile and is designed to navigate and cross even the most challenging lesions with unprecedented ease.
Design of the catheter of Agent Paclitaxel-Coated PTCA Balloon
Outstanding Deliverability with the EMERGE Balloon Technology
 
 

Agent Infographic

How it works*

Once the DCB has been deployed, the durable TransPax coating:

1. Ensures that a consistent drug dose is delivered to a lesion*

2. Binds with microtubules to inhibit proliferation of smooth-muscle cells*

3. Enables healing by selectively impacting cells that cause restenosis while allowing healing of endothelial cells*

Infographic of TransPax Coating Technology

Safety and performance*

Enhanced Coating Integrity

Enhanced Coating Integrity*

Designed to improve coating durability and drug transfer efficacy, allowing for a lower dosage of Paclitaxel*

Optimized Drug Transfer

Optimized Drug Transfer°

Balanced hydrophobic and hydrophilic properties allow efficient drug transfer to the vessel wall

Minimized Systemic Loss

Minimized Systemic Loss§

Less particulates and systemic loss while optimizing arterial tissue Paclitaxel levels.

* Drug coating designed to deliver therapeutic drug dose in association with balloon angioplasty treatment. Data on file at Boston Scientific.
° Data on file at Boston Scientific. Pre-clinical results may not be necessarily indicative of clinical outcomes.
§ Bench testing performed by Boston Scientific. Results not necessarily indicative of clinical performance.

Compliance Chart

AGENT compliance chart

Ordering Information

Balloon Length

Ø(mm)12mm15mm20mm30mm
2.00H74939222201210H74939222201510H74939222202010H74939222203010
2.25H74939222221210H74939222221510H74939222222010H74939222223010
2.50H74939222251210H74939222251510H74939222252010H74939222253010
2.75H74939222271210H74939222271510H74939222272010H74939222273010
3.00H74939222301210H74939222301510H74939222302010H74939222303010
3.50H74939222351210H74939222351510H74939222352010H74939222353010
4.00H74939222401210H74939222401510H74939222402010H74939222403010

† Data on file at Boston Scientific. Pre-clinical results may not be necessarily indicative of clinical outcomes. Hemoteq Coating Process Validation by HPLC. Data on file at Hemoteq. 
‡ 3 μg/mm2 dose for both B Braun SeQuent Please and Biotronik Pantera Lux per manufacturer’s website.
§Method: balloons delivered in a coronary track model with fluid recirculation of 150 ml/min at T = 37 ˚C. Particulates are collected with a polycarbonate filter 5.0 μm x 47 mm (Sterilitech).

Bench test results may not necessarily be indicative of clinical performance.

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